Drug interactions
Methamphetamine + Risperidone
Severity: Moderate
Methamphetamine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone blocks D2 receptors while methamphetamine increases dopamine release, so they may antagonise each other and psychosis control may worsen. Risperidone is also a CYP2D6 substrate, and methamphetamine may add to cardiovascular effects.
What this interaction means in plain words
Methamphetamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic actions at dopamine receptors.
What to do
Monitor for worsening psychosis and for blood pressure and heart rate changes. Titrate doses to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Methamphetamine with Risperidone?
MediHelp rates the interaction as moderate. Methamphetamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone blocks D2 receptors while methamphetamine increases dopamine release, so they may antagonise each other and psychosis control may worsen. Risperidone is also a CYP2D6 substrate, and methamphetamine may add to cardiovascular effects.
How serious is the interaction between Methamphetamine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening psychosis and for blood pressure and heart rate changes. Titrate doses to clinical response.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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