Drug interactions
Methamphetamine + Trazodone
Severity: Major
Methamphetamine and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine increases release of monoamines including serotonin, and trazodone is a serotonergic antidepressant, so the combination may precipitate serotonin syndrome and hypertensive or cardiovascular stress. Opposing sedative effects may also mask intoxication or sedation.
What this interaction means in plain words
Methamphetamine and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methamphetamine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic and sympathomimetic activity, with possible CYP2D6-mediated pharmacokinetic effects.
What to do
Avoid the combination where possible. If used, monitor for agitation, tremor, hyperthermia, tachycardia and hypertension, and stop one agent if serotonin toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Trazodone?
MediHelp rates the interaction as major. Methamphetamine and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methamphetamine increases release of monoamines including serotonin, and trazodone is a serotonergic antidepressant, so the combination may precipitate serotonin syndrome and hypertensive or cardiovascular stress. Opposing sedative effects may also mask intoxication or sedation.
How serious is the interaction between Methamphetamine and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor for agitation, tremor, hyperthermia, tachycardia and hypertension, and stop one agent if serotonin toxicity develops.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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