Drug interactions
Methylprednisolone + Ocrelizumab
Severity: Moderate
Methylprednisolone and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab depletes B cells, and high-dose corticosteroids add to immunosuppression, potentially increasing the risk of infection. Methylprednisolone is routinely given before ocrelizumab infusions to reduce infusion reactions, so short premedication courses are expected.
What this interaction means in plain words
Methylprednisolone and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Ocrelizumab belongs to Central Nervous System.
Why it happens
Additive immunosuppression from B-cell depletion by ocrelizumab and broad corticosteroid immunosuppression.
What to do
Use methylprednisolone as labeled for infusion premedication and avoid prolonged high-dose courses where possible. Monitor for signs of infection and screen for hepatitis B before treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Methylprednisolone with Ocrelizumab?
MediHelp rates the interaction as moderate. Methylprednisolone and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab depletes B cells, and high-dose corticosteroids add to immunosuppression, potentially increasing the risk of infection. Methylprednisolone is routinely given before ocrelizumab infusions to reduce infusion reactions, so short premedication courses are expected.
How serious is the interaction between Methylprednisolone and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use methylprednisolone as labeled for infusion premedication and avoid prolonged high-dose courses where possible. Monitor for signs of infection and screen for hepatitis B before treatment.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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