Drug interactions
Metoclopramide + Midazolam
Severity: Moderate
Metoclopramide and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam causes sedation and respiratory depression, and metoclopramide adds CNS depressant effects. Metoclopramide also speeds gastric emptying, which may hasten absorption of oral midazolam.
What this interaction means in plain words
Metoclopramide and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression, with faster gastric emptying potentially increasing oral midazolam absorption.
What to do
Monitor sedation level and respiration, and titrate midazolam cautiously. Reduce the midazolam dose where needed in elderly or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Metoclopramide with Midazolam?
MediHelp rates the interaction as moderate. Metoclopramide and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam causes sedation and respiratory depression, and metoclopramide adds CNS depressant effects. Metoclopramide also speeds gastric emptying, which may hasten absorption of oral midazolam.
How serious is the interaction between Metoclopramide and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiration, and titrate midazolam cautiously. Reduce the midazolam dose where needed in elderly or frail patients.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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