Drug interactions
Metoclopramide + Mirabegron
Severity: Moderate
Metoclopramide and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate CYP2D6 inhibitor and can raise concentrations of CYP2D6 substrates. Metoclopramide exposure may therefore rise, increasing the risk of extrapyramidal symptoms and sedation, though the inhibition is weaker than with strong inhibitors.
What this interaction means in plain words
Metoclopramide and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing metabolism of metoclopramide.
What to do
Monitor for extrapyramidal symptoms and sedation, and consider a lower metoclopramide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Metoclopramide with Mirabegron?
MediHelp rates the interaction as moderate. Metoclopramide and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirabegron is a moderate CYP2D6 inhibitor and can raise concentrations of CYP2D6 substrates. Metoclopramide exposure may therefore rise, increasing the risk of extrapyramidal symptoms and sedation, though the inhibition is weaker than with strong inhibitors.
How serious is the interaction between Metoclopramide and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation, and consider a lower metoclopramide dose.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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