Drug interactions
Metoclopramide + Nabilone
Severity: Moderate
Metoclopramide and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone is a synthetic cannabinoid that causes drowsiness, dizziness and mood changes. Combined with metoclopramide, additive sedation and impaired cognition can occur.
What this interaction means in plain words
Metoclopramide and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel on additive sedation and avoid driving or hazardous tasks. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Nabilone
Frequently asked questions
Can I take Metoclopramide with Nabilone?
MediHelp rates the interaction as moderate. Metoclopramide and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone is a synthetic cannabinoid that causes drowsiness, dizziness and mood changes. Combined with metoclopramide, additive sedation and impaired cognition can occur.
How serious is the interaction between Metoclopramide and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving or hazardous tasks. Use the lowest effective doses.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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