Drug interactions
Metoclopramide + Nitrofurantoin
Severity: Minor
Metoclopramide and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying and may reduce the time oral nitrofurantoin has to dissolve and be absorbed. Any reduction in absorption is probably small and of uncertain clinical importance.
What this interaction means in plain words
Metoclopramide and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoclopramide belongs to Gastrointestinal Tract; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Accelerated gastrointestinal transit may reduce dissolution and absorption of oral nitrofurantoin.
What to do
No routine change is needed. If the urinary tract infection responds poorly, review whether metoclopramide is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Metoclopramide with Nitrofurantoin?
MediHelp rates the interaction as minor. Metoclopramide and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide speeds gastric emptying and may reduce the time oral nitrofurantoin has to dissolve and be absorbed. Any reduction in absorption is probably small and of uncertain clinical importance.
How serious is the interaction between Metoclopramide and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. If the urinary tract infection responds poorly, review whether metoclopramide is needed.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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