Drug interactions
Metoclopramide + Pentazocine
Severity: Moderate
Metoclopramide and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentazocine causes sedation and respiratory depression and can slow gastrointestinal motility. Together with metoclopramide, CNS depression is additive and prokinetic efficacy is reduced.
What this interaction means in plain words
Metoclopramide and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and opposing gut motility effects.
What to do
Monitor sedation and respiratory rate, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Metoclopramide with Pentazocine?
MediHelp rates the interaction as moderate. Metoclopramide and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentazocine causes sedation and respiratory depression and can slow gastrointestinal motility. Together with metoclopramide, CNS depression is additive and prokinetic efficacy is reduced.
How serious is the interaction between Metoclopramide and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and use the lowest effective doses.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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