Drug interactions
Metoclopramide + Temazepam
Severity: Moderate
Metoclopramide and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide and benzodiazepines both depress the CNS, and combined use may cause excess sedation and psychomotor impairment. Metoclopramide may also modestly speed absorption of some oral benzodiazepines.
What this interaction means in plain words
Metoclopramide and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible faster absorption due to accelerated gastric emptying.
What to do
Monitor for oversedation and consider a lower temazepam dose in older or frail patients. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Metoclopramide with Temazepam?
MediHelp rates the interaction as moderate. Metoclopramide and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide and benzodiazepines both depress the CNS, and combined use may cause excess sedation and psychomotor impairment. Metoclopramide may also modestly speed absorption of some oral benzodiazepines.
How serious is the interaction between Metoclopramide and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider a lower temazepam dose in older or frail patients. Counsel against driving and alcohol.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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