Drug interactions
Metoclopramide + Tipranavir
Severity: Moderate
Metoclopramide and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, may inhibit CYP2D6 and raise metoclopramide exposure, increasing the risk of extrapyramidal symptoms and sedation. Ritonavir is a CYP2D6 inhibitor, though the effect of the boosted combination is mixed and a strong effect is predicted rather than proven.
What this interaction means in plain words
Metoclopramide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Tipranavir belongs to Anti Virals.
Why it happens
Possible inhibition of CYP2D6-mediated metoclopramide metabolism by the ritonavir-boosted regimen.
What to do
Use the lowest effective metoclopramide dose for the shortest time and monitor for extrapyramidal symptoms, restlessness and sedation. Reduce the dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Metoclopramide with Tipranavir?
MediHelp rates the interaction as moderate. Metoclopramide and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, may inhibit CYP2D6 and raise metoclopramide exposure, increasing the risk of extrapyramidal symptoms and sedation. Ritonavir is a CYP2D6 inhibitor, though the effect of the boosted combination is mixed and a strong effect is predicted rather than proven.
How serious is the interaction between Metoclopramide and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective metoclopramide dose for the shortest time and monitor for extrapyramidal symptoms, restlessness and sedation. Reduce the dose if adverse effects appear.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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