Drug interactions
Metoclopramide + Tizanidine
Severity: Moderate
Metoclopramide and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, dizziness and hypotension, so combined use may increase drowsiness and impair alertness. The interaction is usually manageable.
What this interaction means in plain words
Metoclopramide and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive central nervous system depressant effects.
What to do
Start with low doses, monitor sedation and blood pressure, and counsel on driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Metoclopramide with Tizanidine?
MediHelp rates the interaction as moderate. Metoclopramide and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, dizziness and hypotension, so combined use may increase drowsiness and impair alertness. The interaction is usually manageable.
How serious is the interaction between Metoclopramide and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses, monitor sedation and blood pressure, and counsel on driving and machinery.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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