Drug interactions
Metoclopramide + Ziconotide
Severity: Moderate
Metoclopramide and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide commonly causes dizziness, confusion and sedation, and serious neuropsychiatric effects. Metoclopramide adds CNS effects such as drowsiness and restlessness, which may worsen or mask these symptoms.
What this interaction means in plain words
Metoclopramide and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant and neuropsychiatric effects.
What to do
Monitor cognitive status and level of consciousness, and reduce or stop the sedating agent if impairment develops. Consider a different antiemetic if CNS symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Metoclopramide with Ziconotide?
MediHelp rates the interaction as moderate. Metoclopramide and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide commonly causes dizziness, confusion and sedation, and serious neuropsychiatric effects. Metoclopramide adds CNS effects such as drowsiness and restlessness, which may worsen or mask these symptoms.
How serious is the interaction between Metoclopramide and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognitive status and level of consciousness, and reduce or stop the sedating agent if impairment develops. Consider a different antiemetic if CNS symptoms emerge.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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