Drug interactions
Metolazone + Vitamin d
Severity: Moderate
Metolazone and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone reduces urinary calcium excretion and, with vitamin D supplementation, can lead to hypercalcemia. The risk is greater with high vitamin D doses, active analogs or renal impairment.
What this interaction means in plain words
Metolazone and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazide-type diuretics increase distal tubular calcium reabsorption while vitamin D increases intestinal calcium absorption, producing additive calcium elevation.
What to do
Monitor serum calcium periodically, especially at initiation and with dose changes. Reduce or stop vitamin D or the diuretic if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Vitamin d
Frequently asked questions
Can I take Metolazone with Vitamin d?
MediHelp rates the interaction as moderate. Metolazone and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone reduces urinary calcium excretion and, with vitamin D supplementation, can lead to hypercalcemia. The risk is greater with high vitamin D doses, active analogs or renal impairment.
How serious is the interaction between Metolazone and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially at initiation and with dose changes. Reduce or stop vitamin D or the diuretic if hypercalcemia develops.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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