Drug interactions
Metoprolol + Propofol
Severity: Moderate
Metoprolol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and metoprolol limits compensatory heart rate and contractility responses. Hypotension and bradycardia during induction may be more pronounced.
What this interaction means in plain words
Metoprolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive cardiovascular depression from propofol and beta-blockade.
What to do
Continue beta-blocker perioperatively where indicated, and titrate propofol slowly while monitoring blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoprolol and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Propofol
Frequently asked questions
Can I take Metoprolol with Propofol?
MediHelp rates the interaction as moderate. Metoprolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and metoprolol limits compensatory heart rate and contractility responses. Hypotension and bradycardia during induction may be more pronounced.
How serious is the interaction between Metoprolol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue beta-blocker perioperatively where indicated, and titrate propofol slowly while monitoring blood pressure and heart rate.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
