Drug interactions
Metoprolol + Tasimelteon
Severity: Moderate
Metoprolol and Tasimelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers given at night suppress endogenous melatonin secretion, which may reduce the effect of tasimelteon, a melatonin receptor agonist. Sleep-promoting efficacy in Non-24 may be diminished.
What this interaction means in plain words
Metoprolol and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Tasimelteon belongs to Central Nervous System.
Why it happens
Beta-adrenergic blockade lowers nocturnal melatonin production, pharmacodynamically opposing tasimelteon.
What to do
Consider giving the beta-blocker in the morning where clinically appropriate. Monitor sleep-wake response to tasimelteon.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tasimelteon
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Metoprolol with Tasimelteon?
MediHelp rates the interaction as moderate. Metoprolol and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers given at night suppress endogenous melatonin secretion, which may reduce the effect of tasimelteon, a melatonin receptor agonist. Sleep-promoting efficacy in Non-24 may be diminished.
How serious is the interaction between Metoprolol and Tasimelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider giving the beta-blocker in the morning where clinically appropriate. Monitor sleep-wake response to tasimelteon.
What other medicines interact with Tasimelteon?
MediHelp also lists interactions of Tasimelteon with, for example, Carbamazepine, Ciprofloxacin, Enzalutamide. The full list is on the Tasimelteon page.
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