Drug interactions
Metyrosine + Midazolam
Severity: Moderate
Metyrosine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine causes sedation, and combined use with midazolam enhances CNS depression. Drowsiness and psychomotor impairment may be more marked.
What this interaction means in plain words
Metyrosine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metyrosine belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
Why it happens
Additive sedation from catecholamine depletion by metyrosine and GABAergic effects of midazolam.
What to do
Use reduced midazolam doses and monitor sedation. Counsel patients on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Chlorpromazine + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
Frequently asked questions
Can I take Metyrosine with Midazolam?
MediHelp rates the interaction as moderate. Metyrosine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrosine causes sedation, and combined use with midazolam enhances CNS depression. Drowsiness and psychomotor impairment may be more marked.
How serious is the interaction between Metyrosine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced midazolam doses and monitor sedation. Counsel patients on avoiding driving and alcohol.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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