Drug interactions
Metyrosine + Perphenazine
Severity: Moderate
Metyrosine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine depletes catecholamines and can cause extrapyramidal symptoms, and its labeling warns about combined use with phenothiazines. The combination may increase the risk and severity of parkinsonism and dystonia.
What this interaction means in plain words
Metyrosine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metyrosine belongs to Miscellaneous; Perphenazine belongs to Central Nervous System.
Why it happens
Additive dopamine depletion by metyrosine and dopamine receptor blockade by perphenazine.
What to do
Monitor for extrapyramidal symptoms and reduce the dose of either drug if they develop. Consider an alternative to perphenazine if symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Chlorpromazine + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
Frequently asked questions
Can I take Metyrosine with Perphenazine?
MediHelp rates the interaction as moderate. Metyrosine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrosine depletes catecholamines and can cause extrapyramidal symptoms, and its labeling warns about combined use with phenothiazines. The combination may increase the risk and severity of parkinsonism and dystonia.
How serious is the interaction between Metyrosine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and reduce the dose of either drug if they develop. Consider an alternative to perphenazine if symptoms persist.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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