Drug interactions
Metyrosine + Tizanidine
Severity: Moderate
Metyrosine and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine depletes catecholamines and causes sedation and orthostatic hypotension. Tizanidine adds sedative and hypotensive effects, so excessive drowsiness and low blood pressure are more likely.
What this interaction means in plain words
Metyrosine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metyrosine belongs to Miscellaneous; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive sedation and hypotension from tyrosine hydroxylase inhibition and central alpha-2 agonism.
What to do
Monitor blood pressure and sedation, particularly during metyrosine titration. Reduce the tizanidine dose if excessive sedation or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Chlorpromazine + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
Frequently asked questions
Can I take Metyrosine with Tizanidine?
MediHelp rates the interaction as moderate. Metyrosine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrosine depletes catecholamines and causes sedation and orthostatic hypotension. Tizanidine adds sedative and hypotensive effects, so excessive drowsiness and low blood pressure are more likely.
How serious is the interaction between Metyrosine and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, particularly during metyrosine titration. Reduce the tizanidine dose if excessive sedation or hypotension occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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