Drug interactions
Midazolam + Pacritinib
Severity: Moderate
Midazolam and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib may inhibit CYP3A4 and raise midazolam levels, causing deeper and longer sedation. The effect is expected to be clinically important, especially with oral midazolam.
What this interaction means in plain words
Midazolam and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Pacritinib belongs to Oncology.
Why it happens
Pacritinib inhibition of CYP3A4 reduces midazolam clearance.
What to do
Use a lower midazolam dose and titrate carefully, monitoring sedation and respiratory status. Consider lorazepam or another non-CYP3A4 benzodiazepine if prolonged use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Midazolam with Pacritinib?
MediHelp rates the interaction as moderate. Midazolam and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib may inhibit CYP3A4 and raise midazolam levels, causing deeper and longer sedation. The effect is expected to be clinically important, especially with oral midazolam.
How serious is the interaction between Midazolam and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower midazolam dose and titrate carefully, monitoring sedation and respiratory status. Consider lorazepam or another non-CYP3A4 benzodiazepine if prolonged use is needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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