Drug interactions
Midazolam + Rotigotine
Severity: Moderate
Midazolam and Rotigotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotigotine can cause somnolence, sudden sleep onset and orthostatic hypotension, which may add to the sedation of midazolam. Combined use can worsen drowsiness and impair alertness.
What this interaction means in plain words
Midazolam and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Rotigotine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from dopamine agonism and GABA-A potentiation.
What to do
Monitor sedation and blood pressure, and use the lowest effective midazolam dose. Warn patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Midazolam and Rotigotine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Rotigotine
- Amisulpride + Rotigotine Major
- Metoclopramide + Rotigotine Major
- Amlodipine-benazepril + Rotigotine Moderate
- Benazepril + Rotigotine Moderate
- Captopril-hydrochlorothiazide + Rotigotine Moderate
- Captopril + Rotigotine Moderate
Frequently asked questions
Can I take Midazolam with Rotigotine?
MediHelp rates the interaction as moderate. Midazolam and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rotigotine can cause somnolence, sudden sleep onset and orthostatic hypotension, which may add to the sedation of midazolam. Combined use can worsen drowsiness and impair alertness.
How serious is the interaction between Midazolam and Rotigotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and use the lowest effective midazolam dose. Warn patients about driving and operating machinery.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
