Drug interactions
Midazolam + Teclistamab
Severity: Moderate
Midazolam and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab releases cytokines that can transiently suppress CYP450 enzymes, which may increase midazolam exposure and sedation. The risk is greatest during step-up dosing and cytokine release syndrome.
What this interaction means in plain words
Midazolam and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces midazolam clearance.
What to do
Monitor sedation and respiration after teclistamab initiation and during CRS, and lower midazolam doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Midazolam and Teclistamab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Midazolam with Teclistamab?
MediHelp rates the interaction as moderate. Midazolam and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab releases cytokines that can transiently suppress CYP450 enzymes, which may increase midazolam exposure and sedation. The risk is greatest during step-up dosing and cytokine release syndrome.
How serious is the interaction between Midazolam and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiration after teclistamab initiation and during CRS, and lower midazolam doses as needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
