Drug interactions
Midazolam + Vilazodone
Severity: Minor
Midazolam and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilazodone may cause somnolence and dizziness, which can add to midazolam sedation. Vilazodone is a weak CYP3A4 inhibitor, so a small rise in midazolam exposure is also theoretically possible.
What this interaction means in plain words
Midazolam and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible minor CYP3A4 inhibition by vilazodone.
What to do
Monitor sedation after midazolam administration and use the lowest effective dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Midazolam with Vilazodone?
MediHelp rates the interaction as minor. Midazolam and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilazodone may cause somnolence and dizziness, which can add to midazolam sedation. Vilazodone is a weak CYP3A4 inhibitor, so a small rise in midazolam exposure is also theoretically possible.
How serious is the interaction between Midazolam and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after midazolam administration and use the lowest effective dose.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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