Drug interactions
Midodrine + Modafinil
Severity: Moderate
Midodrine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can raise blood pressure: modafinil has sympathomimetic-like effects and can increase blood pressure and heart rate, while midodrine is an alpha-1 agonist vasopressor. Together they may produce additive hypertension, including supine hypertension in patients treated for orthostatic hypotension.
What this interaction means in plain words
Midodrine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Modafinil belongs to Central Nervous System.
Why it happens
Additive pressor effects from alpha-1 adrenergic vasoconstriction (midodrine) and modafinil's catecholaminergic stimulation.
What to do
Monitor blood pressure, including supine readings, when starting or adjusting either drug. Reduce the midodrine dose or stop modafinil if sustained hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Modafinil?
MediHelp rates the interaction as moderate. Midodrine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can raise blood pressure: modafinil has sympathomimetic-like effects and can increase blood pressure and heart rate, while midodrine is an alpha-1 agonist vasopressor. Together they may produce additive hypertension, including supine hypertension in patients treated for orthostatic hypotension.
How serious is the interaction between Midodrine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, when starting or adjusting either drug. Reduce the midodrine dose or stop modafinil if sustained hypertension develops.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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