Drug interactions
Midodrine + Oxycodone
Severity: Minor
Midodrine and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No meaningful pharmacokinetic or direct sedative interaction is established between these drugs. Midodrine is a peripheral alpha-1 agonist that does not substantially counter opioid sedation.
What this interaction means in plain words
Midodrine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midodrine belongs to Miscellaneous; Oxycodone belongs to Musculoskeletal.
Why it happens
No established mechanism; theoretical pharmacodynamic opposition on blood pressure effects only.
What to do
No specific action beyond routine monitoring of blood pressure and opioid effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Oxycodone?
MediHelp rates the interaction as minor. Midodrine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No meaningful pharmacokinetic or direct sedative interaction is established between these drugs. Midodrine is a peripheral alpha-1 agonist that does not substantially counter opioid sedation.
How serious is the interaction between Midodrine and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond routine monitoring of blood pressure and opioid effects.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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