Drug interactions
Midodrine + Propylhexedrine
Severity: Moderate
Midodrine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled sympathomimetic decongestant and midodrine is an alpha-1 agonist, so systemic absorption could add to pressor effects. Elevated blood pressure and reflex bradycardia are possible.
What this interaction means in plain words
Midodrine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Propylhexedrine belongs to Respiratory.
Why it happens
Additive adrenergic vasoconstrictor effects.
What to do
Avoid regular decongestant use with midodrine and monitor blood pressure if it is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Midodrine with Propylhexedrine?
MediHelp rates the interaction as moderate. Midodrine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is an inhaled sympathomimetic decongestant and midodrine is an alpha-1 agonist, so systemic absorption could add to pressor effects. Elevated blood pressure and reflex bradycardia are possible.
How serious is the interaction between Midodrine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular decongestant use with midodrine and monitor blood pressure if it is needed.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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