Drug interactions
Midodrine + Risperidone
Severity: Moderate
Midodrine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone's alpha-1 blockade can cause orthostatic hypotension, while midodrine is an alpha-1 agonist used to raise blood pressure, so the two have opposing effects. Risperidone may reduce midodrine's benefit in orthostatic hypotension.
What this interaction means in plain words
Midodrine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenergic receptors.
What to do
Monitor supine and standing blood pressure and adjust the midodrine dose. Consider a lower risperidone dose or an alternative antipsychotic if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Risperidone?
MediHelp rates the interaction as moderate. Midodrine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone's alpha-1 blockade can cause orthostatic hypotension, while midodrine is an alpha-1 agonist used to raise blood pressure, so the two have opposing effects. Risperidone may reduce midodrine's benefit in orthostatic hypotension.
How serious is the interaction between Midodrine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and adjust the midodrine dose. Consider a lower risperidone dose or an alternative antipsychotic if hypotension persists.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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