Drug interactions
Midodrine + Trazodone
Severity: Moderate
Midodrine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist and trazodone has alpha-1 blocking properties, so they may oppose each other. This can reduce the pressor benefit of midodrine in orthostatic hypotension.
What this interaction means in plain words
Midodrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Trazodone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenergic receptors.
What to do
Monitor standing and supine blood pressure and adjust midodrine if the response is blunted. Consider an alternative to trazodone in patients with orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Trazodone?
MediHelp rates the interaction as moderate. Midodrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist and trazodone has alpha-1 blocking properties, so they may oppose each other. This can reduce the pressor benefit of midodrine in orthostatic hypotension.
How serious is the interaction between Midodrine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and supine blood pressure and adjust midodrine if the response is blunted. Consider an alternative to trazodone in patients with orthostatic hypotension.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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