Drug interactions
Midostaurin + Sevoflurane
Severity: Major
Midostaurin and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin can prolong the QT interval, and sevoflurane has a similar effect. Combined use may increase the risk of torsades de pointes during anesthesia.
What this interaction means in plain words
Midostaurin and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Midostaurin belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG perioperatively and avoid other QT-prolonging agents such as certain antiemetics.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Sevoflurane?
MediHelp rates the interaction as major. Midostaurin and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midostaurin can prolong the QT interval, and sevoflurane has a similar effect. Combined use may increase the risk of torsades de pointes during anesthesia.
How serious is the interaction between Midostaurin and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG perioperatively and avoid other QT-prolonging agents such as certain antiemetics.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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