Drug interactions
Mirtazapine + Modafinil
Severity: Minor
Mirtazapine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a wake-promoting agent that weakly induces CYP3A4, which may modestly lower mirtazapine exposure. Their opposing effects on alertness make the net result variable.
What this interaction means in plain words
Mirtazapine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirtazapine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by modafinil may increase mirtazapine clearance; the pharmacodynamic effects on alertness oppose each other.
What to do
Monitor antidepressant response and sleep quality. Adjust the mirtazapine dose only if clinical effect is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Mirtazapine with Modafinil?
MediHelp rates the interaction as minor. Mirtazapine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is a wake-promoting agent that weakly induces CYP3A4, which may modestly lower mirtazapine exposure. Their opposing effects on alertness make the net result variable.
How serious is the interaction between Mirtazapine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and sleep quality. Adjust the mirtazapine dose only if clinical effect is lost.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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