Drug interactions
Mirtazapine + Ozanimod
Severity: Moderate
Mirtazapine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can cause bradycardia and has been associated with QT effects, and mirtazapine may prolong the QTc. The combination could increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Mirtazapine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation and heart rate slowing; the evidence for this is limited.
What to do
Check a baseline ECG and monitor heart rate and rhythm, especially at ozanimod initiation. Correct electrolyte abnormalities and reassess if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Mirtazapine with Ozanimod?
MediHelp rates the interaction as moderate. Mirtazapine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can cause bradycardia and has been associated with QT effects, and mirtazapine may prolong the QTc. The combination could increase arrhythmia risk in susceptible patients.
How serious is the interaction between Mirtazapine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor heart rate and rhythm, especially at ozanimod initiation. Correct electrolyte abnormalities and reassess if QTc lengthens.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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