Drug interactions
Mirtazapine + Pregabalin
Severity: Moderate
Mirtazapine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and dizziness, so together they can produce excessive drowsiness and psychomotor impairment. Respiratory depression is a concern mainly in elderly patients, those with lung disease, or when other CNS depressants are present.
What this interaction means in plain words
Mirtazapine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and titrate gradually, monitoring for sedation and respiratory depression. Take particular care in elderly patients and those with COPD or on opioids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Mirtazapine with Pregabalin?
MediHelp rates the interaction as moderate. Mirtazapine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and dizziness, so together they can produce excessive drowsiness and psychomotor impairment. Respiratory depression is a concern mainly in elderly patients, those with lung disease, or when other CNS depressants are present.
How serious is the interaction between Mirtazapine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate gradually, monitoring for sedation and respiratory depression. Take particular care in elderly patients and those with COPD or on opioids.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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