Drug interactions
Mirtazapine + Rizatriptan
Severity: Moderate
Mirtazapine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonergic antidepressant with a triptan has been linked theoretically to serotonin syndrome. Documented cases are rare, and mirtazapine acts mainly through receptor antagonism rather than reuptake inhibition.
What this interaction means in plain words
Mirtazapine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity via 5-HT1B/1D agonism with enhancement of noradrenergic and serotonergic transmission.
What to do
Counsel the patient to report agitation, tremor, sweating, diarrhea or fever promptly. Stop both drugs and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Mirtazapine with Rizatriptan?
MediHelp rates the interaction as moderate. Mirtazapine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonergic antidepressant with a triptan has been linked theoretically to serotonin syndrome. Documented cases are rare, and mirtazapine acts mainly through receptor antagonism rather than reuptake inhibition.
How serious is the interaction between Mirtazapine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating, diarrhea or fever promptly. Stop both drugs and treat if serotonin syndrome is suspected.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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