Drug interactions
Mirtazapine + Ruxolitinib
Severity: Minor
Mirtazapine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is not a clinically meaningful CYP3A4 inhibitor, so an important increase in ruxolitinib exposure is not expected. No established clinical interaction exists.
What this interaction means in plain words
Mirtazapine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirtazapine belongs to Central Nervous System; Ruxolitinib belongs to Oncology.
Why it happens
Theoretical CYP3A4 effect; clinical significance not established.
What to do
No dose adjustment is needed; monitor blood counts as usual for ruxolitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Mirtazapine with Ruxolitinib?
MediHelp rates the interaction as minor. Mirtazapine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirtazapine is not a clinically meaningful CYP3A4 inhibitor, so an important increase in ruxolitinib exposure is not expected. No established clinical interaction exists.
How serious is the interaction between Mirtazapine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood counts as usual for ruxolitinib.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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