Drug interactions
Mirtazapine + Stiripentol
Severity: Moderate
Mirtazapine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and may also induce CYP1A2 and CYP3A4, two of the main enzymes that clear mirtazapine. Mirtazapine exposure may therefore rise or fall unpredictably, causing excess sedation or reduced antidepressant effect.
What this interaction means in plain words
Mirtazapine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP1A2 and CYP3A4 activity (inhibition and induction), altering mirtazapine metabolism.
What to do
Monitor for sedation and for loss of antidepressant response when starting, stopping or changing the stiripentol dose. Adjust the mirtazapine dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Mirtazapine with Stiripentol?
MediHelp rates the interaction as moderate. Mirtazapine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and may also induce CYP1A2 and CYP3A4, two of the main enzymes that clear mirtazapine. Mirtazapine exposure may therefore rise or fall unpredictably, causing excess sedation or reduced antidepressant effect.
How serious is the interaction between Mirtazapine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for loss of antidepressant response when starting, stopping or changing the stiripentol dose. Adjust the mirtazapine dose according to clinical response.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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