Drug interactions
Mirtazapine + Tedizolid
Severity: Moderate
Mirtazapine and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid has weak MAO-inhibiting activity and mirtazapine enhances serotonergic and noradrenergic transmission. The combination could in theory precipitate serotonin syndrome. Studies in animals and healthy volunteers showed little serotonergic effect with tedizolid, and clinical experience is limited.
What this interaction means in plain words
Mirtazapine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic activity from weak reversible MAO inhibition by tedizolid and enhanced monoamine transmission from mirtazapine.
What to do
Where possible choose a non-serotonergic antibiotic. If co-prescribed, monitor for neuromuscular excitability, hyperthermia and mental status changes and stop one agent if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mirtazapine and Tedizolid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Tedizolid?
MediHelp rates the interaction as moderate. Mirtazapine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid has weak MAO-inhibiting activity and mirtazapine enhances serotonergic and noradrenergic transmission. The combination could in theory precipitate serotonin syndrome. Studies in animals and healthy volunteers showed little serotonergic effect with tedizolid, and clinical experience is limited.
How serious is the interaction between Mirtazapine and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose a non-serotonergic antibiotic. If co-prescribed, monitor for neuromuscular excitability, hyperthermia and mental status changes and stop one agent if serotonin toxicity is suspected.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
