Drug interactions
Mirtazapine + Trazodone
Severity: Moderate
Mirtazapine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, and trazodone has a known risk of ventricular arrhythmia. They are also both sedating and may raise serotonergic toxicity risk, though this combination is commonly used at night in practice.
What this interaction means in plain words
Mirtazapine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, additive sedation and possible additive serotonergic effects.
What to do
Use the lowest effective doses and check ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Counsel on sedation and falls and watch for serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Mirtazapine with Trazodone?
MediHelp rates the interaction as moderate. Mirtazapine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, and trazodone has a known risk of ventricular arrhythmia. They are also both sedating and may raise serotonergic toxicity risk, though this combination is commonly used at night in practice.
How serious is the interaction between Mirtazapine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and check ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Counsel on sedation and falls and watch for serotonin toxicity.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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