Drug interactions
Mitomycin + Sarecycline
Severity: Minor
Mitomycin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is reported to inhibit P-glycoprotein in vitro, which could theoretically raise mitomycin exposure. The clinical relevance is uncertain given sarecycline's typical use for acne and its low systemic exposure.
What this interaction means in plain words
Mitomycin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mitomycin belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by sarecycline reducing mitomycin efflux.
What to do
No routine change is needed; monitor blood counts as usual during mitomycin therapy and reassess if unexpected toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Mitomycin with Sarecycline?
MediHelp rates the interaction as minor. Mitomycin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is reported to inhibit P-glycoprotein in vitro, which could theoretically raise mitomycin exposure. The clinical relevance is uncertain given sarecycline's typical use for acne and its low systemic exposure.
How serious is the interaction between Mitomycin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood counts as usual during mitomycin therapy and reassess if unexpected toxicity occurs.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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