Drug interactions
Mitomycin + Vinblastine
Severity: Major
Mitomycin and Vinblastine: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acute dyspnea and severe bronchospasm have been reported when vinca alkaloids are given to patients who have received mitomycin, before or concurrently. The reaction can be serious and may appear soon after the vinca dose or later.
What this interaction means in plain words
Mitomycin and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitomycin belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
The mechanism is unknown, but additive or synergistic pulmonary toxicity is suspected.
What to do
Monitor respiratory status closely and treat bronchospasm promptly with bronchodilators and corticosteroids. Stop therapy if serious pulmonary toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vinblastine
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Mitomycin with Vinblastine?
MediHelp rates the interaction as major. Mitomycin and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acute dyspnea and severe bronchospasm have been reported when vinca alkaloids are given to patients who have received mitomycin, before or concurrently. The reaction can be serious and may appear soon after the vinca dose or later.
How serious is the interaction between Mitomycin and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status closely and treat bronchospasm promptly with bronchodilators and corticosteroids. Stop therapy if serious pulmonary toxicity develops.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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