Drug interactions
Modafinil + Nevirapine
Severity: Minor
Modafinil and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower modafinil exposure, potentially reducing its wakefulness-promoting effect. The effect is predicted from the mechanism and is rarely dramatic.
What this interaction means in plain words
Modafinil and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, which contributes to modafinil clearance.
What to do
Monitor for reduced alertness and increase the modafinil dose if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Nevirapine?
MediHelp rates the interaction as minor. Modafinil and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine induces CYP3A4 and may lower modafinil exposure, potentially reducing its wakefulness-promoting effect. The effect is predicted from the mechanism and is rarely dramatic.
How serious is the interaction between Modafinil and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced alertness and increase the modafinil dose if clinically needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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