Drug interactions
Modafinil + Omaveloxolone
Severity: Moderate
Modafinil and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may reduce omaveloxolone exposure and possibly its benefit in Friedreich ataxia. Labeling advises avoiding moderate or strong CYP3A4 inducers.
What this interaction means in plain words
Modafinil and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Omaveloxolone belongs to Central Nervous System.
Why it happens
Modafinil induces CYP3A4, increasing omaveloxolone clearance.
What to do
Avoid if possible; otherwise monitor clinical response and consider an alternative wakefulness agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Modafinil with Omaveloxolone?
MediHelp rates the interaction as moderate. Modafinil and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil may reduce omaveloxolone exposure and possibly its benefit in Friedreich ataxia. Labeling advises avoiding moderate or strong CYP3A4 inducers.
How serious is the interaction between Modafinil and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor clinical response and consider an alternative wakefulness agent.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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