Drug interactions
Modafinil + Oxycodone
Severity: Moderate
Modafinil and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may induce CYP3A4 and could modestly lower oxycodone exposure, reducing analgesic effect. Its wake-promoting action may also mask opioid sedation without reducing respiratory depression.
What this interaction means in plain words
Modafinil and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Weak CYP3A4 induction by modafinil increases oxycodone metabolism; opposing CNS effects.
What to do
Monitor analgesic response and adjust the oxycodone dose if needed. Watch for opioid toxicity if modafinil is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Oxycodone?
MediHelp rates the interaction as moderate. Modafinil and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil may induce CYP3A4 and could modestly lower oxycodone exposure, reducing analgesic effect. Its wake-promoting action may also mask opioid sedation without reducing respiratory depression.
How serious is the interaction between Modafinil and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust the oxycodone dose if needed. Watch for opioid toxicity if modafinil is stopped.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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