Drug interactions
Modafinil + Ozanimod
Severity: Moderate
Modafinil and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and combining it with sympathomimetic or monoaminergic agents raises concern for hypertensive reactions. Modafinil has mild sympathomimetic effects, though the clinical risk is probably limited.
What this interaction means in plain words
Modafinil and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Theoretical additive adrenergic effects with MAO-B inhibition; not well established clinically.
What to do
Monitor blood pressure and heart rate when starting or adjusting the combination. Choose an alternative if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Modafinil with Ozanimod?
MediHelp rates the interaction as moderate. Modafinil and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, and combining it with sympathomimetic or monoaminergic agents raises concern for hypertensive reactions. Modafinil has mild sympathomimetic effects, though the clinical risk is probably limited.
How serious is the interaction between Modafinil and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting the combination. Choose an alternative if blood pressure rises.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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