Drug interactions
Modafinil + Propylhexedrine
Severity: Minor
Modafinil and Propylhexedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is a sympathomimetic nasal decongestant, and with modafinil it may add to stimulation and blood pressure rise. Systemic exposure is modest at normal doses.
What this interaction means in plain words
Modafinil and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Additive sympathomimetic and CNS stimulation.
What to do
Use the decongestant at labeled doses and monitor blood pressure in hypertensive patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Modafinil with Propylhexedrine?
MediHelp rates the interaction as minor. Modafinil and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propylhexedrine is a sympathomimetic nasal decongestant, and with modafinil it may add to stimulation and blood pressure rise. Systemic exposure is modest at normal doses.
How serious is the interaction between Modafinil and Propylhexedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the decongestant at labeled doses and monitor blood pressure in hypertensive patients.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
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