Drug interactions
Modafinil + Risperidone
Severity: Minor
Modafinil and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause somnolence and modafinil promotes wakefulness, so their effects oppose each other. Modafinil may worsen agitation or psychotic symptoms in some patients, and no important pharmacokinetic interaction is established.
What this interaction means in plain words
Modafinil and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal.
What to do
No dose change is generally needed. Monitor psychiatric status and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Modafinil and Risperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Modafinil
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Modafinil with Risperidone?
MediHelp rates the interaction as minor. Modafinil and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Risperidone can cause somnolence and modafinil promotes wakefulness, so their effects oppose each other. Modafinil may worsen agitation or psychotic symptoms in some patients, and no important pharmacokinetic interaction is established.
How serious is the interaction between Modafinil and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor psychiatric status and sedation.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
