Drug interactions
Modafinil + Tramadol
Severity: Moderate
Modafinil and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil induces CYP3A4 and may lower tramadol concentrations, possibly reducing its analgesic effect. Modafinil has a stimulant effect and tramadol may lower the seizure threshold.
What this interaction means in plain words
Modafinil and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by modafinil increasing tramadol clearance.
What to do
Monitor analgesic response and adjust the tramadol dose if pain control is inadequate. Watch for seizures in predisposed patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Tramadol?
MediHelp rates the interaction as moderate. Modafinil and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil induces CYP3A4 and may lower tramadol concentrations, possibly reducing its analgesic effect. Modafinil has a stimulant effect and tramadol may lower the seizure threshold.
How serious is the interaction between Modafinil and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust the tramadol dose if pain control is inadequate. Watch for seizures in predisposed patients.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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