Drug interactions
Modafinil + Triclabendazole
Severity: Minor
Modafinil and Triclabendazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole and its metabolites may inhibit CYP2C19, an enzyme that contributes to modafinil clearance. Modafinil exposure could therefore rise modestly, increasing the risk of adverse effects such as headache, nausea, anxiety and insomnia. Triclabendazole is given as a short course so the effect is temporary.
What this interaction means in plain words
Modafinil and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2C19-mediated metabolism of modafinil by triclabendazole.
What to do
Monitor for modafinil adverse effects such as insomnia, anxiety and headache during the triclabendazole course. Reduce the modafinil dose if tolerability problems appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Triclabendazole
Frequently asked questions
Can I take Modafinil with Triclabendazole?
MediHelp rates the interaction as minor. Modafinil and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclabendazole and its metabolites may inhibit CYP2C19, an enzyme that contributes to modafinil clearance. Modafinil exposure could therefore rise modestly, increasing the risk of adverse effects such as headache, nausea, anxiety and insomnia. Triclabendazole is given as a short course so the effect is temporary.
How serious is the interaction between Modafinil and Triclabendazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects such as insomnia, anxiety and headache during the triclabendazole course. Reduce the modafinil dose if tolerability problems appear.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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