Drug interactions
Modafinil + Trimipramine
Severity: Moderate
Modafinil and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may modestly increase tricyclic concentrations in some patients, particularly poor CYP2D6 metabolisers, through inhibition of CYP2C19. Their sedative and stimulant effects also oppose one another, so the net clinical effect is unpredictable.
What this interaction means in plain words
Modafinil and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Possible modafinil inhibition of CYP2C19 reducing tricyclic clearance, plus opposing central effects.
What to do
Monitor for anticholinergic and cardiovascular adverse effects and consider checking tricyclic levels or lowering the dose if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Trimipramine?
MediHelp rates the interaction as moderate. Modafinil and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil may modestly increase tricyclic concentrations in some patients, particularly poor CYP2D6 metabolisers, through inhibition of CYP2C19. Their sedative and stimulant effects also oppose one another, so the net clinical effect is unpredictable.
How serious is the interaction between Modafinil and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic and cardiovascular adverse effects and consider checking tricyclic levels or lowering the dose if toxicity is suspected.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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