Drug interactions
Momelotinib + Nitrofurantoin
Severity: Minor
Momelotinib and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP, and nitrofurantoin is a BCRP substrate, so nitrofurantoin exposure may increase. The clinical impact is expected to be small for typical short treatment courses.
What this interaction means in plain words
Momelotinib and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Momelotinib belongs to Oncology; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Momelotinib inhibits intestinal and renal BCRP efflux, potentially raising nitrofurantoin exposure.
What to do
No routine dose adjustment is needed; watch for nitrofurantoin adverse effects such as gastrointestinal upset or neuropathy, particularly with renal impairment or long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Nitrofurantoin?
MediHelp rates the interaction as minor. Momelotinib and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Momelotinib inhibits BCRP, and nitrofurantoin is a BCRP substrate, so nitrofurantoin exposure may increase. The clinical impact is expected to be small for typical short treatment courses.
How serious is the interaction between Momelotinib and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; watch for nitrofurantoin adverse effects such as gastrointestinal upset or neuropathy, particularly with renal impairment or long-term use.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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