Drug interactions
Momelotinib + Tacrolimus
Severity: Moderate
Momelotinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may inhibit OATP1B1/1B3 and raise momelotinib exposure. This could increase momelotinib adverse effects such as thrombocytopenia, infection and gastrointestinal events.
What this interaction means in plain words
Momelotinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Momelotinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake transporters reduces momelotinib clearance.
What to do
Monitor blood counts and momelotinib adverse effects, and reduce or interrupt momelotinib per labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Tacrolimus?
MediHelp rates the interaction as moderate. Momelotinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may inhibit OATP1B1/1B3 and raise momelotinib exposure. This could increase momelotinib adverse effects such as thrombocytopenia, infection and gastrointestinal events.
How serious is the interaction between Momelotinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and momelotinib adverse effects, and reduce or interrupt momelotinib per labeling if toxicity develops.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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