Drug interactions
Montelukast + Peginterferon alfa 2b
Severity: Minor
Montelukast and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2b can suppress hepatic CYP activity, which could alter montelukast clearance. Any change is unpredictable and probably small.
What this interaction means in plain words
Montelukast and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Montelukast belongs to Respiratory; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Interferon-mediated downregulation of hepatic CYP enzymes may alter montelukast metabolism; not well characterized.
What to do
No dose adjustment is needed. Monitor asthma control and tolerability during interferon therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Montelukast with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Montelukast and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2b can suppress hepatic CYP activity, which could alter montelukast clearance. Any change is unpredictable and probably small.
How serious is the interaction between Montelukast and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor asthma control and tolerability during interferon therapy.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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